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Plasma factor VII and its relation to adipose tissue fatty acids and other atherogenic risk factors in healthy men
Author(s) -
CIGOLINI M.,
TARGHER G.,
SEIDELL J. C.,
SCHIAVON R.,
TONOLI M.,
MUGGEO M.,
DE SANDRE G.
Publication year - 1996
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1046/j.1365-2362.1996.147279.x
Subject(s) - medicine , adipose tissue , endocrinology , polyunsaturated fatty acid , triglyceride , fatty acid , chemistry , docosapentaenoic acid , body mass index , waist , docosahexaenoic acid , cholesterol , biochemistry
In this study the authors examined the relationships of plasma factor VII (F–VII) to adipose tissue fatty acid composition, as an objective index of the habitual dietary fat intake, as well as to a number of other atherogenic risk factors in 60 healthy male volunteers (aged 38 years). Significant positive correlations were found between plasma F‐VII [measured as antigen (F‐VIIAg) and coagulant activity, using bovine thromboplastin (F‐VIIbt)] and body mass index (BMI), waist–thigh girth ratio (WTR), cigarette smoking and plasma triglyceride concentration. After adjustment for BMI, only plasma triglycerides remained positively correlated with F‐VII ( r = 0.27, P = 0.03, and r = 0.29, P < 0.01, for F‐VIIbt and F‐VIIAg respectively). A significant positive relation was found between F‐VII and the total proportion of fatty acid as monounsaturated fatty acid ( r = 0.26, P < 0.05, for F‐VIIAg), whereas inverse relations were found between F‐VII, the total proportion of fatty acid as polyunsaturated fatty acid ( r = − 0.26 and r = − 0.25, P < 0.05, for F‐VIIbt and F‐VIIAg respectively), polyunsaturated–saturated fat ratio ( r = − 0.25, P < 0.05, for F‐VIIbt) and, more significantly, between F‐VII and adipose‐tissue α‐linolenic acid ( r = − 0.29, P < 0.01, for F‐VIIbt and r = − 0.49, P < 0.001, for F‐VIIAg). All these correlations remained significant after matching for BMI. In a multiple linear regression analysis, only adipose tissue α‐linolenic acid was a negative and independent predictor of F‐VIIAg ( P = 0.004) and, at borderline significance, of F‐VIIbt ( P = 0.061) when allowance was made for BMI, WTR, smoking and plasma triglycerides. In conclusion, this study shows significant relations between F‐VII and adipose tissue fatty acid composition in healthy male individuals; it supports the possibility that adipose tissue poly‐ unsaturated fatty acids, derived from dietary intake, play a role in the relation between F‐VII and coronary heart disease (CHD), thus suggesting that high dietary polyunsaturated fatty acid intake (especially α‐linolenic acid) may reduce the risk for CHD by an improvement of a number of risk factors, including a lowering of plasma F‐VII (both activity and antigen).