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Growth hormone potentiates the in vivo biological activities of endotoxin in the rat
Author(s) -
LIAO W.,
RUDLING M.,
ANGELIN B.
Publication year - 1996
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1046/j.1365-2362.1996.140268.x
Subject(s) - in vivo , hormone , growth hormone , pharmacology , biological activity , endocrinology , medicine , chemistry , biology , in vitro , biochemistry , microbiology and biotechnology
To investigate if growth hormone (GH) alters the effects of endotoxin in rats, endotoxin (5 mg kg −1 body weight) was injected into normal rats and into rats primed with GH for 3 days. Endotoxin had injurious effects on renal and liver function and induced hypoglycaemia and hyperlipidaemia as expected. GH‐primed rats became extremely sick after endotoxin challenge and had more marked abnormalities of renal and liver function and much more pronounced hypoglycaemia and hyperlipidaemia than non‐primed rats. It is concluded that growth hormone potentiates the in vivo biological activities of endotoxin in the rat. The results may also suggest that caution should be exerted when considering GH treatment in catabolic situations with endotoxaemia and that special attention should be paid to the prevention of infection during GH therapy in such situations.