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Hormone receptor status in breast cancer – a comparison between surgical specimens and fine needle aspiration biopsies
Author(s) -
Löfgren L.,
Skoog L.,
Schoultz E.,
Tani E.,
Isaksson E.,
Fernstad R.,
Carlström K.,
Schoultz B.
Publication year - 2003
Publication title -
cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.512
H-Index - 48
eISSN - 1365-2303
pISSN - 0956-5507
DOI - 10.1046/j.1365-2303.2003.00054.x
Subject(s) - medicine , fine needle aspiration , breast cancer , concordance , oestrogen receptor , staining , biopsy , hormone receptor , immunohistochemistry , pathology , receptor , mammary gland , progesterone receptor , cancer , gynecology , estrogen receptor
The present study was performed to evaluate the immunocytochemical analysis (ICA) of oestrogen (ER) and progesterone receptor (PR) in fine needle aspiration (FNA) biopsies from primary breast cancers as compared with the established enzyme immunoassays (ER‐EIA and PR‐EIA) based on cytosol homogenates from the corresponding resected tumour specimens. A total of 967 primary breast cancers were assessed for ER and PR content by both methods. Correlations between EIA and ICA expressed as percentage of tumour cells with a positive staining were highly significant ( P < 0.001) for ER and PR. Staining intensity yielded only limited additional information. The concordance between the two techniques was about 80%. Evaluation of biological parameters by FNA may be useful to decide the optimal treatment for breast cancer patients.