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Evaluation of liquid‐based cytology in cervical screening of high‐risk populations: a split study of colposcopy and genito‐urinary medicine populations
Author(s) -
RING M.,
BOLGER N.,
O'DONNELL M.,
MALKIN A.,
BERMINGHAM N.,
AKPAN E.,
MULCAHY F.,
TURNER M. J.,
GRIFFIN M.,
O'LEARY J. J.
Publication year - 2002
Publication title -
cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.512
H-Index - 48
eISSN - 1365-2303
pISSN - 0956-5507
DOI - 10.1046/j.1365-2303.2002.00408.x
Subject(s) - colposcopy , medicine , cytology , gynecology , outpatient clinic , obstetrics , urinary system , cervical intraepithelial neoplasia , cervical cancer , pathology , cancer
A split study evaluated the ThinPrep ® PapTest™ (TP; Cytyc Corp., Boxborough, MA) compared with current methodologies of cervical cytology in two high‐risk cohorts. One thousand, three hundred cases from a colposcopy clinic and a genito‐urinary medicine outpatient clinic were examined. The TP reported increased detection of all grades of dyskaryosis (mild, moderate and severe; + 4.5%) and a decrease in borderline and unsuitable cases (− 4.9%). Four cases of high‐grade dyskaryosis (moderate or severe) were detected only using the TP, while an additional four cases classified as high‐grade dyskaryosis with the TP were reported as borderline by our conventional methods. The split‐study finding of increased sensitivity with the TP provides for improved clinical management of patients in our high‐risk cohorts.