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Efficacy of Ki‐67 antigen staining in Papanicolaou (Pap) smears in post‐menopausal women with atypia—an audit
Author(s) -
Ejersbo D.,
Jensen H. A.,
Hølund B.
Publication year - 1999
Publication title -
cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.512
H-Index - 48
eISSN - 1365-2303
pISSN - 0956-5507
DOI - 10.1046/j.1365-2303.1999.00205.x
Subject(s) - medicine , papanicolaou stain , atypia , colposcopy , ki 67 , staining , gynecology , vaginal smear , papanicolaou test , pathology , immunohistochemistry , cervical cancer , cancer , estrous cycle
Efficacy of Ki‐67 antigen staining in Papanicolaou (Pap) smears in post‐menopausal women with atypia—an audit In cervical smears from post‐menopausal women with mucosal atrophy it can be difficult to distinguish atrophic epithelial cell groups from neoplastic cell groups on cytomorphological criteria only. The consequence of post‐menopausal atypia is that the woman is referred for a repeat smear after local oestrogen treatment or for colposcopy. We investigated whether immunocytochemical expression of Ki‐67 (MIB‐1) on the primary Papanicolaou‐stained smear could be of any diagnostic help. Our data showed that negative Ki‐67 expression is a very reliable indicator of a normal atrophic cell pattern, and by using this method on the original smear we were able to reduce the false‐positive cytologic diagnoses by 86%.