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Expression of Cathepsin D and pS2 in imprint smears of breast carcinoma
Author(s) -
Athanassiadou P. P.,
Athanassiades P. H.,
Davaris P.,
Petrakakou E. I.,
Zerva CH. I.,
Kyrkou K. A.
Publication year - 1998
Publication title -
cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.512
H-Index - 48
eISSN - 1365-2303
pISSN - 0956-5507
DOI - 10.1046/j.1365-2303.1998.00110.x
Subject(s) - cathepsin d , medicine , breast carcinoma , pathology , lymph node , malignancy , immunohistochemistry , carcinoma , cytopathology , metastasis , breast cancer , biology , cancer , cytology , biochemistry , enzyme
athanassiadou p.p., athanassiades p. h., daffaris p., petrakakou e. i., fflerffa ch. i. and kffirkou k. a. (1998) Cytopathology 9, 240–247 Expression of Cathepsin D and pS2 in imprint smears of breast carcinoma The aim of this study was to add to existing information on the effects of certain tumour markers expressed by breast cancers on tumour malignancy as evidenced by size of primary and occurrence of lymph node invasion. One hundred freshly resected breast cancers were examined by immunocytochemical staining of imprint smears for Cathepsin D and pS2. Oestrogen receptor (ER) and progesterone receptor (PR) were tested for by dextrose‐coated charcoal (DCC) assay and the results correlated with tumour size, histology and presence or absence of lymph node metastases at the time of surgery using χ 2 analysis. A significant positive correlation was demonstrated between Cathepsin D positivity and ER, PR and pS2 positivity. In tumours < 2 cm in diameter at surgery a positive correlation was observed between Cathepsin D positivity and the presence of lymph node metastases. The findings support the hypothesis that Cathepsin D may promote early metastasis, possibly by its proteolytic activity.