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DNA ploidy and pS 2 protein expression in breast cancer
Author(s) -
IOAKIMLIOSSI A.,
KARAKITSOS P.,
ARONI K.,
MARKOPOULOS C.,
DELIVELIOTI K.,
GOGAS J.,
KYRKOU K.
Publication year - 1997
Publication title -
cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.512
H-Index - 48
eISSN - 1365-2303
pISSN - 0956-5507
DOI - 10.1046/j.1365-2303.1997.44175441.x
Subject(s) - medicine , ploidy , breast cancer , cancer research , protein expression , oncology , cancer , expression (computer science) , dna , biology , genetics , gene , computer science , programming language
The DNA content of ductal breast carcinomas of varying histological grade was measured using static image cytometry and correlated with pS 2 expression in the tumour cells. Our study was performed on imprint of surgical biopsies of 60 women with ductal breast cancer. A statistically significant difference was observed between pS 2 + expression and grade of malignancy ( P <0.001). The percentage of euploid tumours significantly decreased from grade I to grade II to grade III ( P =0.01). The percentage of aneuploid tumours increased from pS 2 + to pS 2 − breast tumours ( P <0.001). These findings may be indicative of pS 2 and DNA ploidy alterations and tumour aggressiveness.