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Effects of exercise training on aerobic and functional capacity of end‐stage renal disease patients
Author(s) -
Koufaki Pelagia,
Mercer Thomas H.,
Naish Patrick F.
Publication year - 2002
Publication title -
clinical physiology and functional imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.608
H-Index - 67
eISSN - 1475-097X
pISSN - 1475-0961
DOI - 10.1046/j.1365-2281.2002.00405.x
Subject(s) - medicine , aerobic capacity , end stage renal disease , cycle ergometer , analysis of variance , aerobic exercise , vo2 max , physical therapy , anaerobic exercise , ventilatory threshold , cardiology , heart rate , hemodialysis , blood pressure
The aim was to assess the effects of exercise training on aerobic and functional capacity of patients with end‐stage renal disease (ESRD). Patients completed an incremental exercise test on a cycle ergometer to determine VO 2 peak and VO 2 at ventilatory threshold (VT; V‐slope). On a separate day they performed two constant load exercise tests on a cycle ergometer at 90% of VT and at a workload of 33 W, to determine VO 2 kinetics. Functional capacity was assessed using measurements of sit‐to‐stands (STS‐5, STS‐60) and a walk test. Dialysis patients were randomly allocated to an exercise (ET: n =18, age=57·3 years) or control (C: n =15, age=50·5 years) group. The ET group participated in an exercise training programme involving cycling for 3 months. Repeated measures ANOVA revealed significant time by group interactions ( P < 0·05) following training for VO 2 peak (ET: 17 ± 6·1 versus 19·9 ± 6·3, C: 19·5 ± 4·7 versus 18·8 ± 4·9 ml kg min –1 ) and VO 2 –VT (ET: 10·7 ± 3·5 versus 11·8 ± 3·3, C:12·9 ± 3·2 versus 11·9 ± 3·5 ml kg min –1 ). VO 2 kinetics remained unchanged in both groups at 90% ‐VT, but a trend ( P =0·059) towards faster kinetics at the 33 W was observed (ET: 49·6 ± 19·5 versus 37·8 ± 12·7, C: 42·8 ± 13 versus 49·4 ± 20·2 s). Significant time by group interactions ( P < 0·05) were also observed for STS‐5 (ET: 14·7 ± 6·2 versus 11·0 ± 3·3, C: 12·8 ± 4·4 versus 12·7 ± 4·8 s) and STS‐60 measurements (ET: 21·2 ± 7·2 versus 26·9 ± 6·2, C: 23·7 ± 6·8 versus 24·1 ± 7·2). Three months of exercise rehabilitation significantly improves peak exercise capacity of patients with ESRD. Measurements of VO 2 kinetics and functional capacity suggest that longer time might be needed to induce peripheral adaptations.