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Predictors of intellectual outcome in a cohort of brazilian children with congenital hypothyroidism
Author(s) -
Kreisner E.,
Schermann L.,
CamargoNeto E.,
Gross J. L.
Publication year - 2004
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1046/j.1365-2265.2004.01974.x
Subject(s) - intelligence quotient , cohort , medicine , pediatrics , wechsler adult intelligence scale , congenital hypothyroidism , outpatient clinic , intellectual disability , cohort study , stanford–binet intelligence scales , intellectual development , cognition , psychiatry , psychology , developmental psychology , thyroid
Summary objective To identify predictors of intellectual development in a cohort of children with permanent primary congenital hypothyroidism. design Cohort study with intellectual development as the outcome. patients and measurements Thirty‐one consecutive newborns with permanent primary congenital hypothyroidism diagnosed by a screening programme were recruited from the outpatient clinic of a district hospital and underwent psychometric evaluation with the Wechsler Intelligence Scales after a minimum follow‐up of 4 years. results Eight of the 31 patients (25·8%) presented impaired intellectual development (full‐scale intellectual quotient < 85), and one of them presented mental deficiency (full‐scale intellectual quotient ≤ 69). The following were associated with worse prognosis: initial serum T4 levels ≤ 32·18 nmol/l, treatment beginning after 30 days of age, fewer than seven clinic visits during the first year of life, living in rural areas, nonintellectual parental occupation and little parental schooling. In a multiple regression analysis, only maternal schooling (B = 0·401; β coefficient = 13·053, P = 0·063), number of clinic visits during the first year of life (B = 0·382; β coefficient = 4·145, P = 0·047) and initial serum T4 (B = 0·287; β coefficient = 1·336, P = 0·089) remained significantly associated with full‐scale intelligence quotient scores. conclusion Maternal schooling, number of visits during the first year of life and baseline T4 levels were the main predictors of cognitive outcome in this cohort of patients.