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Fibrous bodies are associated with lower GH production and decreased expression of E‐cadherin in GH‐producing pituitary adenomas
Author(s) -
Nishioka Hiroshi,
Haraoka Jo,
Akada Kiyohiro
Publication year - 2003
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1046/j.1365-2265.2003.01921.x
Subject(s) - medicine , endocrinology , immunohistochemistry , prolactin , adenoma , basal (medicine) , cytokeratin , acromegaly , prolactinoma , bromocriptine , biology , hormone , growth hormone , insulin
Summary objective A retrospective study was conducted in order to elucidate the clinicopathological significance of fibrous bodies, a hallmark of the sparsely granulated variant of GH‐producing pituitary adenomas. methods A total of 37 acromegalic patients, 14 men and 23 women, with pure GH adenomas were studied. Immunohistochemistry was performed with antibodies specific for cytokeratin 8 and 18 (CAM5·2), GH, prolactin and E‐cadherin. The tumour volume was estimated with high‐resolution magnetic resonance imaging. results The percentages of adenoma cells with dot‐like immunoreactivity for CAM5·2, fibrous bodies, were variable, ranging continuously from 0 to 100%. An increased percentage was associated with a lower basal GH level per unit tumour volume, a lower GH response to a bromocriptine suppression test, decreased immunoreactivities for GH and prolactin, and a decreased expression of E‐cadherin immunoreactivity. conclusion GH adenomas could not be distinctly separated into those with or without fibrous bodies. Decreased expression of E‐cadherin may be involved in formation of fibrous bodies and result in lower GH production.