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Association of two apolipoprotein A‐I gene Msp I polymorphisms with high density lipoprotein (HDL)‐cholesterol levels and indices of obesity in selected healthy Chinese subjects and in patients with early‐onset type 2 diabetes
Author(s) -
Ma Yan Qing,
Thomas G Neil,
Ng Maggie C. Y.,
Critchley Julian A. J. H.,
Cockram Clive S.,
Chan Juliana C. N.,
Tomlinson Brian
Publication year - 2003
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1046/j.1365-2265.2003.01865.x
Subject(s) - medicine , endocrinology , obesity , body mass index , apolipoprotein b , high density lipoprotein , waist , cholesterol , polymorphism (computer science) , genotype , allele , lipoprotein , lipid profile , biology , gene , genetics
Summary objective Previous studies have reported associations between two apolipoprotein A‐I (apoA‐I) gene Msp I polymorphisms (G‐75A and C83T) and high density lipoprotein (HDL)‐cholesterol and/or apoA‐I levels, but have not investigated the relationship with obesity. methods We determined the distribution of these polymorphisms in 482 early‐onset (≤ 40 years) Type 2 Chinese diabetics and 167 Chinese selected healthy controls. results The −75A and 83T allele frequencies were similar in the diabetic and healthy subjects. In the healthy control subjects, HDL‐cholesterol levels were significantly higher in the AA homozygotes than in the GG/GA carriers (1·74 ± 0·58 vs. 1·45 ± 0·58 mmol/l, P < 0·001). Furthermore, analyses showed a significant relationship between increasing HDL‐cholesterol tertiles and the AA genotype frequency in the selected healthy subjects (3·6, 8·9 and 16·1%, P = 0·026). For the C83T polymorphism, healthy male CT carriers had higher HDL‐cholesterol levels than CC homozygotes (1·71 ± 0·57 vs. 1·25 ± 0·30 mmol/l, P = 0·001), but this was not found in females. No relationship between these polymorphisms and lipid levels was found in the diabetics, who had a more adverse lipid profile than the selected controls. In the diabetics, but not the controls, in CT carriers compared to CC homozygotes there were lower levels of body mass index (BMI; 23·8 ± 3·9 vs. 25·4 ± 4·7 kg/m 2 , P = 0·048) and waist‐to‐height ratio (0·49 ± 0·06 vs. 0·52 ± 0·07, P = 0·023), and this relationship was supported by tertile analysis. conclusions The −75AA genotype was associated with higher HDL‐cholesterol levels in the selected healthy, but not diabetic, subjects. The 83T allele was associated with greater indices of obesity in the diabetic patients, and with higher HDL‐cholesterol in heterozygous healthy male subjects.