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Increased Interleukin‐6 levels in pituitary‐deficient patients are independently related to their carotid intima‐media thickness
Author(s) -
Leonsson M.,
Hulthe J.,
Johannsson G.,
Wiklund O.,
Wikstrand J.,
Bengtsson B. Å.,
Oscarsson J.
Publication year - 2003
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1046/j.1365-2265.2003.01832.x
Subject(s) - medicine , endocrinology , fibrinogen , body mass index , intima media thickness , plasminogen activator , plasminogen activator inhibitor 1 , tissue plasminogen activator , carotid arteries
Summary objective Increased cardiovascular morbidity and mortality has been observed in patients with pituitary deficiency and untreated growth hormone deficiency (GHD). We investigated peripheral inflammatory and fibrinolytic markers and their associations with arterial intima‐media thickness (IMT) in GHD. design Cross‐sectional study. patients Thirty‐four patients with GHD, but without cardiovascular disease, were compared to healthy controls matched for age, sex, body mass index (BMI) and smoking habits. measurements IMT of the common carotid artery, C‐reactive protein (CRP), interleukin‐6 (IL‐6), fibrinogen, plasminogen activator inhibitor‐1 (PAI‐1) activity and tissue plasminogen activator antigen (tPA‐ag) were measured. results Median IL‐6 concentrations were increased by 208% and 248% in GHD patients compared to BMI‐matched and nonobese controls, respectively. Median CRP and tPA‐ag levels were increased by 237% and 167% in patients compared to nonobese controls, but not significantly different compared to BMI‐matched controls. Plasma levels of fibrinogen and PAI‐1 activity did not differ between groups. Age, low‐density lipoprotein (LDL) cholesterol, tPA‐ag and IL‐6 were positively correlated, and IGF‐I was negatively correlated to IMT in the patient group, but only age and IL‐6 were independently related to IMT. conclusions IL‐6 concentrations were increased in GHD patients compared to controls and independently related to IMT in patients. This finding may help to explain the variance in IMT and the increased vascular morbidity and mortality in hypopituitary patients with GHD.