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Ectopic growth hormone‐releasing hormone secretion by thymic carcinoid tumour
Author(s) -
Boix E.,
Picó A.,
Pinedo R.,
Aranda I.,
Kovacs K.
Publication year - 2002
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1046/j.1365-2265.2002.01535.x
Subject(s) - endocrinology , medicine , acromegaly , somatostatin , hormone , growth hormone–releasing hormone , multiple endocrine neoplasia , secretion , immunohistochemistry , men1 , biology , endocrine system , growth hormone , gene , biochemistry
Summary The case of a 33‐year‐old‐woman with Multiple Endocrine Neoplasia Type 1 (MEN1) syndrome and acromegaly due to ectopic growth hormone‐releasing hormone (GHRH) secretion by a thymic carcinoid tumour is reported. Immunohistochemistry revealed positive immunoreactivity for GHRH, vasoactive intestinal polypeptide, somatostatin and alpha‐subunit in the tumour cells. A previously undescribed new germ line mutation of the MEN1 protein gene was revealed.