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The contribution of IGF‐I to skeletal integrity in postmenopausal women
Author(s) -
MuñozTorres Manuel,
MezquitaRaya Pedro,
LopezRodriguez Francisca,
TorresVela Elena,
De Dios Luna Juan,
EscobarJimenez Fernando
Publication year - 2001
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1046/j.1365-2265.2001.01390.x
Subject(s) - medicine , osteoporosis , bone mineral , calcaneus , femoral neck , densitometry , bone density , menopause , endocrinology , urology , surgery
OBJECTIVES The pathogenic role of the decline in serum concentrations of IGF‐I in postmenopausal osteoporosis is not fully elucidated. We investigated the associations among IGF‐I, bone mineral density (BMD), ultrasound parameters and prevalence of vertebral fractures in postmenopausal women. DESIGN A cross‐sectional study. PATIENTS One hundred and fifty‐four ambulatory postmenopausal women (61 ± 7 years) referred for osteoporosis screening. MEASUREMENTS IGF‐I was measured by radioimmunoassay and BMD using dual‐energy X‐ray absorptiometry. Broadband ultrasound attenuation (BUA) and speed of sound (SOS) at calcaneus were measured by a quantitative ultrasound system. RESULTS IGF‐I was significantly lower in osteoporotic subjects and correlated positively with BMD, BUA and SOS. After adjusting for age, years since menopause and body mass index, IGF‐I accounted for 8·5% of the variance at lumbar spine BMD, 4·6% at femoral neck and 7·1% at calcaneal BUA. BUA was associated with IGF‐I independently of BMD. IGF‐I was lower in women with vertebral fractures (91 ± 39 µg/l vs. 114 ± 44 µg/l; P = 0·003). The osteoporosis densitometric criteria ( t ‐score ≤ −2·5 SD) was the most strongly independent associated variable with prevalent vertebral fractures [odds ratio (OR): 3·3 (1·4–7·6)], followed by IGF‐I levels below 75th percentile [OR: 3 (1–8·8)]. CONCLUSIONS Our study shows that IGF‐I is strongly associated with bone mineral density and reflects aspects of bone quality. The contribution of IGF‐I to skeletal integrity in postmenopausal women is clinically relevant.