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Interleukin‐6 (IL‐6) producing phaeochromocytoma: direct IL‐6 suppression by non‐steroidal anti‐inflammatory drugs
Author(s) -
Shimizu Chikara,
Kubo Mitsumasa,
Takano Kazuhiko,
Takano Akiko,
Kijima Hiromichi,
Saji Hiroshi,
Katsuyama Itaru,
Sasano Hironobu,
Koike Takao
Publication year - 2001
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1046/j.1365-2265.2001.01082.x
Subject(s) - naproxen , anti inflammatory , immunohistochemistry , medicine , in vivo , secretion , interleukin 6 , nonsteroidal , interleukin , endocrinology , inflammation , pharmacology , cytokine , pathology , biology , alternative medicine , microbiology and biotechnology
A 35‐year‐old Japanese woman presented with a phaeochromocytoma and demonstrated marked inflammatory reactions and pyrexia as a result of excessive production of interleukin‐6 (IL‐6) by the tumour. Serum IL‐6 level was 262 ng/l (normal; < 4·0 ng/l). Fever and inflammatory markers were largely overcome by the administration of the nonsteroidal anti‐inflammatory drug, naproxen, and all symptoms disappeared soon after the tumour was excised. Immunohistochemical study revealed positive staining using an antihuman IL‐6 antibody and Northern analysis showed increased IL‐6 mRNA levels in the tumour. Cultured tumour cells showed IL‐6 protein synthesis, and nonsteroidal anti‐inflammatory drugs such as naproxen and indomethacin directly inhibited IL‐6 release. These results indicate that the effects of naproxen in vivo were due, at least in part, to direct suppression of IL‐6 secretion from the tumour.