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Complete histological regression of metastatic carcinoid tumour after treatment with octreotide
Author(s) -
Imtiaz K. E.,
Monteith P.,
Khaleeli A.
Publication year - 2000
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1046/j.1365-2265.2000.01126.x
Subject(s) - medicine , octreotide , carcinoid tumour , carcinoid syndrome , abdominal pain , gastroenterology , colonoscopy , stage (stratigraphy) , abdomen , biopsy , radiology , colorectal cancer , cancer , somatostatin , paleontology , biology
A 69‐year‐old woman was admitted with facial flushing, weight loss and intermittent diarrhoea. Urinary 5‐hydroxyindole‐acetic acid (5‐HIAA) level was elevated at 200 μmol/24 h (normal: < 50). Computerized tomography (CT) demonstrated multiple enhancing liver metastases with biopsy proven carcinoid metastases with no evidence of primary tumour at this stage. Octreotide was initiated, resulting in marked improvement in carcinoid symptoms. Nine years later, she presented with abdominal pain and slightly deranged liver function tests. Repeat colonoscopy at this stage, showed an ileal tumour causing impending obstruction, necessitating urgent right hemicolectomy. Histology demonstrated primary carcinoid tumour. She continued on octreotide. Three years later at the age of 81 years, she suffered a fatal haemorrhagic stroke. Autopsy revealed complete regression of hepatic carcinoid metastases.