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Androgens and penile erection: evidence for a direct relationship between free testosterone and cavernous vasodilation in men with erectile dysfunction
Author(s) -
Aversa A.,
Isidori A. M.,
De Martino M. U.,
Caprio M.,
Fabbrini E.,
RocchiettiMarch M.,
Frajese G.,
Fabbri A.
Publication year - 2000
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1046/j.1365-2265.2000.01118.x
Subject(s) - psychogenic disease , erectile dysfunction , medicine , endocrinology , testosterone (patch) , free androgen index , sex hormone binding globulin , confounding , vasodilation , androgen , urology , hormone , radiology
OBJECTIVE Androgens are essential in the maintenance of nitric oxide‐mediated erectile activity in the rat. The objective of the present study was to investigate the role of androgens in regulating trabecular smooth muscle relaxation in the corpus cavernosum in response to vasoactive challenge in men with erectile dysfunction (ED). DESIGN Retrospective, double‐blind correlation analyses. PATIENTS Fifty‐two impotent patients without confounding risk factors for ED were obtained from a total of 250 undergoing diagnostic evaluation. MEASUREMENTS All patients had dynamic colour duplex ultrasound (D‐CDU) and hormonal evaluation for LH, total and free testosterone, SHBG and oestradiol. RESULTS Based upon D‐CDU results patients were diagnosed as having arteriogenic (AR, n = 18; mean age 51) or corporeal venocclusive (CVO, n = 13; mean age 49) ED; in other patients ( n = 21, mean age 43) a diagnosis of psychogenic (P)‐ED was made by comprehensive psychogenic testing and confirmed by normal D‐CDU results. AR and CVO patients had altered compliance of cavernous arteries recorded by D‐CDU [20–25% lower resistive index (RI) than patients with psychogenic ED], and lower free testosterone (FT) levels than psychogenic patients [42.3 ± 3.5 SE and 49.3 ± 5.2 vs . 75.2 ± 7.6 pmol/l, respectively; P < 0.01]. More important, in all patients there was a strong direct correlation between resistive index values and FT levels ( r = 0.47, P = 0.002); the relationship was maintained also when adjusted for age, SHBG and oestradiol ( r = 0.37, P = 0.02). CONCLUSIONS These results indicate that in men with erectile dysfuntion low free testosterone may correlate independently of age with the impaired relaxation of cavernous endothelial and corporeal smooth muscle cells to a vasoactive challenge. These findings give clinical support to the experimental knowledge of the importance of androgens in regulating smooth muscle function in the penis.