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Giant cell granulamatous hypophysitis with remarkable uptake on Gallium‐67 scintigraphy
Author(s) -
Shimizu Chikara,
Kubo Mitsumasa,
Kijima Hiromichi,
Ishizu Akihiro,
Katoh Tsutomu,
Koike Takao
Publication year - 1998
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1046/j.1365-2265.1998.00417.x
Subject(s) - giant cell , pituitary gland , pathology , scintigraphy , hypophysitis , langhans giant cell , diabetes insipidus , medicine , endocrinology , hormone
We treated a man with giant cell granulomatous hypophysitis with pituitary enlargement, as seen on magnetic resonance imaging. Endocrinological examination revealed panhypopituitarism and diabetes insipidus. Microscopic examination of the specimen obtained by transsphenoidal pituitary biopsy revealed a granulomatous lesion, composed of epitheliod cells, Langhans' multinucleated giant cells, lymphocytes and other chronic inflammatory cells. On whole body gallium‐67 scintigraphy, there was extensive uptake in the pituitary gland. Gallium‐67 scintigraphy may greatly aid in the diagnosis of granulomatous hypophysitis.