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Interleukin‐6 secreting phaeochromocytoma associated with clinical markers of inflammation
Author(s) -
Takagi Miki,
Egawa Takeshi,
Motomura Takashi,
SakumaMochizuki Junko,
Nishimoto Norihiro,
Kasayama Soji,
Hayashi Seiji,
Koga Masafumi,
Yoshizaki Kazuyuki,
Yoshioka Toshiaki,
Okuyama Akihiko,
Kishimoto Tadamitsu
Publication year - 1997
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1046/j.1365-2265.1997.1160931.x
Subject(s) - thrombocytosis , medicine , endocrinology , immunohistochemistry , pheochromocytoma , interleukin 6 , inflammation , fibrinogen , hormone , interleukin , cytokine , platelet
Phaeochromocytomas have been shown to produce not only catecholamines but other neuropeptides and hormones, with a variety of clinical manifestations. We report a 70‐year‐old female patient with phaeochromocytoma exhibiting sustained hypertension, low‐grade fever, thrombocytosis, and elevated levels of plasma fibrinogen and C‐reactive protein. Serum interleukin (IL)‐6 levels were significantly elevated, whereas serum IL‐1α and IL‐β were not detectable. After surgical removal of the tumour, hypertension and low‐grade fever disappeared, and the laboratory findings including serum IL‐6 concentrations became normal. Immunohistochemical study of the tumour showed positive staining for IL‐6. Culture of the resected tumour revealed the production of large amounts of IL‐6. It is suggested that IL‐6 secreted by the tumour was responsible for some of the clinical manifestations in this patient.