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Thyroid involvement by malignant histiocytosis of Langerhans' cell type
Author(s) -
Kitahama Shinji,
Iitaka Makoto,
Shimizu Tadashi,
Serizawa Naoki,
Fukasawa Nobuhiko,
Miura Shiro,
Kawasaki Satomi,
Yamanaka Kayo,
Kawakami Yoshito,
Murakami Saburo,
Ishii Jun,
Katayama Shigehiro
Publication year - 1996
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1046/j.1365-2265.1996.8020819.x
Subject(s) - birbeck granules , langerhans cell histiocytosis , thyroid , medicine , pathology , anaplastic thyroid cancer , malignant histiocytosis , langerhans cell , histiocytosis , endocrinology , histiocyte , thyroid cancer , antigen , immunology , disease
Involvement of the thyroid gland by Langerhans' cell histiocytosis is quite rare. We describe the case of a 58‐year‐old man referred for treatment of a progressively enlarging goitre. The trachea was severely stenotic and adjacent structures such as the left carotid vein and the thyroid cartilage were also involved. Central diabetes insipidus and severe combined immunodeficiency were associated. Although fine needle aspiration biopsy of the thyroid was initially interpreted as papillary carcinoma, anaplastic thyroid cancer was suspected. Treatment with prednisolone, doxorubicin and irradiation controlled the tracheal compression. A diagnosis of thyroid Langerhans' cell histiocytosis was finally made on the basis of the presence of Birbeck granules and CD1a and CD4 antigen in the thyroid tumour cells. Furthermore, positive staining for CD68 and lysozyme suggested that the tumour cells may have had the character of phagocytic cells in addition to their dendritic cell nature. This is the first case of thyroid involvement by malignant histicytosis of Langerhans' cell type with unusual phagocytic markers.