Open AccessClinical and immunological evaluation of patients with mild IgG1 deficiency
Author(s) -
Diana A. van Kessel,
Paul E. Horikx,
A J van Houte,
Casper S. de Graaff,
Heleen van VelzenBlad,
Ger T. Rijkers
Publication year - 1999
Publication title -
clinical & experimental immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.329
H-Index - 135
eISSN - 1365-2249
pISSN - 0009-9104
DOI - 10.1046/j.1365-2249.1999.01023.x
Subject(s) - subclass , immunology , pneumococcal polysaccharide vaccine , medicine , pulmonology , isotype , vaccination , pneumonia , antibody , antigen , pneumococcal vaccine , respiratory tract infections , streptococcus pneumoniae , respiratory system , biology , microbiology and biotechnology , monoclonal antibody , antibiotics , pneumococcal disease
Serum IgG subclass concentrations were determined in patients visiting, the pulmonology out‐patient clinic with chronic respiratory tract problems. A total of 24 patients with a serum IgG1 concentration < 4.9 g/ l (i.e. below the reference range) and normal values for IgG2, IgM and IgA were included. Patients with a selective IgG1 deficiency were vaccinated with a 23‐valent pneumococcal polysaccharide vaccine. There were nine patients with a poor antibody response to pneumococcal capsular polysaccharide antigens. Responsiveness to protein antigens was intact in all patients. Patients with pneumonia showed a significantly lower anti‐polysaccharide response in the IgG2 subclass than patients without pneumonia. Patients with recurrent sinusitis showed a significantly lower response in the IgA isotype after vaccination with pneumococcal polysaccharide vaccine compared with non‐sinusitis patients. It can be concluded that patients with recurrent sinopulmonary infections and a mild IgG1 subclass deficiency have an impaired IgG1 anti‐polysaccharide response, which can extend to decreased IgG2 and IgA anti‐polysaccharide responses.