Open AccessAnti‐oxidative capacity in patients with ataxia telangiectasia
Author(s) -
Janine Reichenbach,
Ralf Schubert,
C Schwan,
Klaus Müller,
Hansjosef Böhles,
Stefan Zielen
Publication year - 1999
Publication title -
clinical & experimental immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.329
H-Index - 135
eISSN - 1365-2249
pISSN - 0009-9104
DOI - 10.1046/j.1365-2249.1999.01000.x
Subject(s) - reactive oxygen species , ataxia telangiectasia , oxidative stress , ubiquinol , antioxidant , immunology , medicine , chemistry , endocrinology , biology , apoptosis , biochemistry , cytochrome c , coenzyme q – cytochrome c reductase , dna damage , dna
Highly reactive oxygen species (ROS) are involved in T‐cell activation and in the defense against environmental pathogens. An imbalance of ROS generation and detoxifying scavenger enzymes could contribute to the increased susceptibility to cancer and infections in ataxia telangiectasia. We studied oxidative status, i.e. plasma total antioxidant capacity (TEAC), retinol, α‐tocopherol, ubiquinol, and the number of activated T cells in 10 patients with ataxia telangiectasia (AT) compared to age‐matched healthy controls. As expected, patients showed significantly increased levels of activated human leukocyte antigen‐DR and CD45RO expressing T cells. TEAC levels as well as the exogenous antioxidants retinol and α‐tocopherol were significantly reduced in patients. In addition, patients showed slightly reduced plasma levels of the endogenous ROS scavenger enzyme ubiquinol (Q10). Although no correlation between number of activated T‐cells and antioxidant capacity could be demonstrated, an increase in ROS and a diminished reactive oxygen scavenger capacity may be involved in the disease process of patients with AT.