Open AccessRelevance of FcγRIIIa‐158V‐F polymorphism to recurrence of adult periodontitis in Japanese patients
Author(s) -
Noriko Sugita,
Kouji Yamamoto,
Tetsuo Kobayashi,
W. Ludo van der Pol,
Tuneyoshi Horigome,
Hiromasa Yoshie,
Jan G. J. van de Winkel,
Kohji Hara
Publication year - 1999
Publication title -
clinical & experimental immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.329
H-Index - 135
eISSN - 1365-2249
pISSN - 0009-9104
DOI - 10.1046/j.1365-2249.1999.00984.x
Subject(s) - cd16 , immunology , genotype , antibody , fc receptor , medicine , immunoglobulin g , receptor , periodontitis , immune system , microbiology and biotechnology , biology , gene , cd8 , cd3 , biochemistry
The immunoglobulin receptor FcγRIIIa (CD16) is distributed on natural killer (NK) cells, macrophages, and γδ T cells, and is polymorphic. FcγRIIIa‐158V has a higher affinity for both monomeric and immune complexed IgG1, IgG3, and IgG4 than IIIa‐158F. We determined FcγRIIIa‐158V/F genotypes of Japanese patients with adult periodontitis. A significant over‐representation of FcγRIIIa‐158F was found in patients with recurrence, compared with patients without recurrence, making FcγRIIIA a candidate gene for recurrence risk of adult periodontitis.