Open AccessEffects of bucillamine and N‐acetyl‐ L ‐cysteine on cytokine production and collagen‐induced arthritis (CIA)
Author(s) -
Fumio Tsuji,
Yurika Miyake,
Hiroyuki Aono,
Yasunaru Kawashima,
Shiro Mita
Publication year - 1999
Publication title -
clinical & experimental immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.329
H-Index - 135
eISSN - 1365-2249
pISSN - 0009-9104
DOI - 10.1046/j.1365-2249.1999.00749.x
Subject(s) - cytokine , arthritis , immunology , chemistry , cysteine , medicine , biochemistry , enzyme
We investigated the effects of bucillamine and N‐acetyl‐ L ‐cysteine (NAC) on cytokine production and CIA. Bucillamine and NAC inhibited NF‐κB activation and tumour necrosis factor‐alpha (TNF‐α) mRNA expression in human monocytic leukaemia cell line THP‐1, and cytokine production from monocyte cell lines at concentrations >10 −3 M . They also inhibited cytokine production and CIA in mice at a dose of 500 mg/kg. These results suggest that NF‐κB inhibitors such as bucillamine and NAC may inhibit cytokine‐related diseases, including arthritis.