Open AccessReduced IL‐1 production in adolescents with mite antigen asthma in remission
Author(s) -
Noma T.,
Ichikawa K.,
Yoshizawa I.,
Aoki K.,
Kawano Y.,
Baba M.
Publication year - 1998
Publication title -
clinical & experimental immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.329
H-Index - 135
eISSN - 1365-2249
pISSN - 0009-9104
DOI - 10.1046/j.1365-2249.1998.00619.x
Subject(s) - immunology , asthma , house dust mite , medicine , antigen , peripheral blood mononuclear cell , mite , lipopolysaccharide , allergy , interleukin 5 , interleukin , in vitro , allergen , cytokine , biology , biochemistry , botany
To determine the immunological mechanisms associated with outgrowing mite antigen‐induced bronchial asthma during adolescence, we studied the relationship between clinical status and Dermatophagoides farinae (Df) antigen‐induced peripheral cell activation by measuring IL‐1α and IL‐lβ production in patients with bronchial asthma. After antigen‐driven restimulation in vitro , there was increased IL‐1α, IL‐1β production by peripheral blood mononuclear cells (PBMC) from patients with active bronchial asthma, while cellular IL‐1α, IL‐1β production was reduced in patients with asthma in remission. IL‐1α and IL‐1β production by PBMC (possibly reflecting airway inflammation) after exposure to Df antigen might be down‐regulated in patients outgrowing mite antigen‐induced asthma, because lipopolysaccharide‐induced IL‐1α, IL‐1β production (seen in both normal individuals and patients with active asthma) was also reduced when patients were in remission.