Open AccessPrevalence and characterization of perinuclear anti‐neutrophil cytoplasmic antibodies (P‐ANCA) directed against HMG1 and HMG2 in ulcerative colitis (UC)
Author(s) -
Junko Sobajima,
Shoichi Ozaki,
Hiroko Uesugi,
Fumio Osakada,
Hitoshi Shirakawa,
Michiteru Yoshida,
Kazuwa Nakao
Publication year - 1998
Publication title -
clinical & experimental immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.329
H-Index - 135
eISSN - 1365-2249
pISSN - 0009-9104
DOI - 10.1046/j.1365-2249.1998.00491.x
Subject(s) - antibody , immunology , ulcerative colitis , autoantibody , antigen , medicine , disease
In a previous study, we reported that the high mobility group (HMG) non‐histone chromosomal proteins HMG1 and HMG2 were novel target antigens of P‐ANCA. In this study, we determined the immunodiagnostic value of anti‐HMG1/HMG2 antibodies in patients with UC. Sixty sera from patients with UC were tested for reactivity with HMG1 and HMG2 by means of ELISA. Anti‐HMG1 antibody was detected in 32% of patients (40% of P‐ANCA + patients). Anti‐HMG2 antibody was detected in 33% (40% of P‐ANCA + patients). Thirty‐five percent of sera were positive for antibody to either HMG1 or HMG2 (43% of P‐ANCA + patients). P‐ANCA + patients expressed anti‐HMG1/HMG2 antibodies with significantly greater frequency compared with P‐ANCA − patients. Furthermore, the anti‐HMG1/HMG2 antibodies were significantly related to disease activity in UC. Sixteen of the 18 UC patients, who had high titres of anti‐HMG1 or ‐HMG2 antibody during the active phase, showed lower titres in the inactive phase. Anti‐HMG1/HMG2 antibodies appear to be useful as a marker for disease activity in UC.