Open AccessCD8 + CD28 − T cells in vertically HIV‐infected children
Author(s) -
BRUGI D.,
AIRO’ P.,
TIMPANO S.,
MALACARNE F.,
UGAZIO A. G.,
CATTANEO R.,
DUSE M.
Publication year - 1997
Publication title -
clinical & experimental immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.329
H-Index - 135
eISSN - 1365-2249
pISSN - 0009-9104
DOI - 10.1046/j.1365-2249.1997.4871386.x
Subject(s) - cd28 , cd8 , immunology , human immunodeficiency virus (hiv) , t lymphocyte , cytotoxic t cell , lymphocyte , medicine , cd4 cd8 ratio , biology , lymphocyte subsets , immune system , in vitro , genetics
To evaluate whether vertical HIV infection interferes with the expression of CD28 on T lymphocytes, 25 HIV‐infected children and 29 seroreverted children born to HIV + mothers were studied. The percentage of CD28 − cells among CD8 + T lymphocytes was higher in HIV‐infected children than in controls ( P < 0.001). In fact, in HIV‐infected children, this percentage was elevated from the first year of life, while in healthy seroreverted children, the proportion of CD28 − cells among CD8 + cells rose progressively with age ( r = 0.49; P = 0.008). In HIV + children, the CD8 + CD28 − , but not CD8 + CD28 + cell proportion was significantly correlated with immunological markers of disease progression, such as CD4 + cell loss ( r = −0.65; P < 0.001) and the level of in vitro spontaneous lymphocyte apoptosis ( r = 0.53; P = 0.03).