Open AccessIncreased plasma levels of soluble CD23 in haemorrhagic fever with renal syndrome; relation to virus‐specific IgE
Author(s) -
ALEXEYEV O. A.,
LINDERHOLM M.,
ELGH F.,
WADELL G.,
JUTO P.,
TÄRNVIK A.
Publication year - 1997
Publication title -
clinical & experimental immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.329
H-Index - 135
eISSN - 1365-2249
pISSN - 0009-9104
DOI - 10.1046/j.1365-2249.1997.4641359.x
Subject(s) - immunology , immunoglobulin e , cd23 , medicine , virus , virology , biology , antibody
In 15 consecutive patients hospitalized with nephropathia epidemica, a European form of haemorrhagic fever with renal syndrome (HFRS) caused by Puumala virus, plasma concentrations of soluble CD23 (sCD23) and Puumala virus‐specific IgE were determined. In the acute phase of illness, 11/15 patients had increased sCD23 levels (> 91 U/ml), whereas in convalescence, values of 8/10 patients were normalized. Maximal sCD23 values were correlated to maximal concentrations of Puumala virus‐specific serum IgE ( r = 0.597; P = 0.025). The results are compatible with a known ability of sCD23 to augment IgE production.