Open AccessHuman peritoneal B‐1 cells and the influence of continuous ambulatory peritoneal dialysis on peritoneal and peripheral blood mononuclear cell (PBMC) composition and immunoglobulin levels
Author(s) -
DONZE H. H.,
LUE C.,
JULIAN B. A.,
KUTTEH W. H.,
KANTELE A.,
MESTECKY J.
Publication year - 1997
Publication title -
clinical & experimental immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.329
H-Index - 135
eISSN - 1365-2249
pISSN - 0009-9104
DOI - 10.1046/j.1365-2249.1997.4541352.x
Subject(s) - immunology , peripheral blood mononuclear cell , population , continuous ambulatory peritoneal dialysis , peritoneal fluid , lymphocyte , peritoneal dialysis , medicine , antigen , antibody , immune system , homing (biology) , peritoneum , biology , pathology , in vitro , biochemistry , environmental health , ecology
In mice, peritoneal B cells are composed of a unique B‐1 cell population which can repopulate the intestinal lamina propria with IgA‐producing cells, as well as contribute to the majority of serum IgM. In this study, peritoneal lymphocytes from patients starting continuous ambulatory peritoneal dialysis (CAPD) and from women undergoing bilateral tubal ligation (BTL) were analysed for the presence of a B‐1 cell population as well as the expression of potential homing receptors. Up to 63% of the peritoneal B cells express surface antigen CD5, and most peritoneal lymphocytes express the mucosal homing receptors, α4β7 and αEβ7. When analysing serial samples collected from patients from the beginning of dialysis to 1 year, no marked changes were observed in serum or salivary immunoglobulin levels, although the peritoneal lymphocyte population was reduced by 50%. These data suggest that the phenotype of human peritoneal B‐1 cells is similar to that of mice, but the contributions to the immune system may differ.