Open AccessRegulatory role of exogenous IL‐10 in the development of immune response versus Cryptococcus neoformans
Author(s) -
MONARI C.,
RETINI C.,
PALAZZETTI B.,
BISTONI F.,
VECCHIRELLI A.
Publication year - 1997
Publication title -
clinical & experimental immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.329
H-Index - 135
eISSN - 1365-2249
pISSN - 0009-9104
DOI - 10.1046/j.1365-2249.1997.4021303.x
Subject(s) - cryptococcus neoformans , immunology , immune system , biology , cryptococcosis , cryptococcus , immunity , microbiology and biotechnology
The most important event involved in host defence against Cryptococcus neoformans is the development of an adequate cell‐mediated immune response. IL‐10, abundantly produced during AIDS progression, could be a negative factor that affects the T cell response through its own immunosuppressive action on antigen‐presenting cells. To determine whether this cytokine affects the course of immune response against C. neoformans , we added exogenous IL‐10 to cultured Cryptococcus ‐laden monocytes plus T lymphocytes. The data from this study confirmed the down‐regulatory effect of exogenous IL‐10 on monocytes and expanded the known inhibitory role to include an increase of the deleterious effect due to capsular material of C. neoformans on (i) lymphoproliferation, (ii) down‐regulation of MHC class II molecules, (iii) inhibition of IL‐2 mRNA expression and protein secretion by T lymphocytes. These results indicate that the presence of IL‐10 in AIDS patients, due to the progression of disease, could represent a pivotal problem contributing to augment the pathogenic effect of C. neoformans .