Open AccessCirculating soluble selectins in Kawasaki disease
Author(s) -
TAKESHITA S.,
DOBASHI H.,
NAKATANI K.,
KOIKE Y.,
TSUJIMOTO H.,
HIRAYAMA K.,
KAWAMURA Y.,
MORI K.,
SEKINE I.,
YOSHIOKA S.
Publication year - 1997
Publication title -
clinical & experimental immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.329
H-Index - 135
eISSN - 1365-2249
pISSN - 0009-9104
DOI - 10.1046/j.1365-2249.1997.3852128.x
Subject(s) - selectin , kawasaki disease , cell adhesion molecule , immunology , platelet , l selectin , medicine , endocrinology , artery
To investigate the significance of circulating adhesion molecules associated with leucocyte–endothelial cell interaction in Kawasaki disease (KD), serum levels of soluble E‐, P‐, L‐selectin (sE‐, sP‐, sL‐selectin), and vascular cell adhesion molecule‐1 (VCAM‐1) were measured in 16 patients with KD, eight with other febrile diseases, six with Henoch–Schönlein purpura (HSP), and 10 healthy children using an ELISA. Serum sE‐selectin levels from patients in the acute phase of KD were significantly higher than from those in other groups ( P <0.01). The levels of sP‐selectin in the subacute phase of KD were significantly higher than in other groups ( P <0.01). Serum sL‐selectin levels tended to rise in the convalescent phase of KD. There were also significant correlations between sE‐selectin levels and C‐reactive protein ( r =0.80, P <0.0001), and between sP‐selectin levels and platelet counts ( r =0.57, P <0.0001) in KD patients. These data indicate that circulating soluble forms of three selectins may have different kinetics during the clinical course of KD, suggesting that they may reflect its inflammatory process.