Open AccessImmunogenicity of HIV‐1 LAI gp160 and env peptides in squirrel monkey Saimiri sciureus using alumine and experimental adjuvants
Author(s) -
PERRAUT R.,
CHOUTEAU P.,
MOOG C.,
BONNEMAINS B.,
KIENY M. P.
Publication year - 1996
Publication title -
clinical & experimental immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.329
H-Index - 135
eISSN - 1365-2249
pISSN - 0009-9104
DOI - 10.1046/j.1365-2249.1996.d01-857.x
Subject(s) - saimiri sciureus , immunogenicity , squirrel monkey , virology , immunology , biology , immune system , ecology
Since the identification of the HIV virus, important advances have been achieved in the definition of potential subunit vaccines. We investigated the immunogenicity of a recombinant gp160 antigen and of two gp41 peptides from HIV‐1 LAI associated with seven different adjuvant formulations in squirrel monkeys. All animals were immunized twice with gp160 and then with a gp41 peptide using the same formulation. All adjuvants used led to a subsequent antibody response against gp160, and 55% of the animals immunized developed anti‐gp160 antibodies that could neutralize the virus in vitro . Specific anti‐gp41 antibody response was also observed. Results obtained underlined the key role of the adjuvant formulation in the antibody response against a given part of the immunogen, and indicate that such immunogenicity‐related investigation can be carried out conveniently in the squirrel monkey Saimiri sciureus .