Open AccessElevated levels of soluble CD14 in serum of patients with acute Plasmodium falciparum malaria
Author(s) -
WENISCH C.,
WENISCH H.,
PARSCHALK B.,
VANIJATA S.,
BURGMANN H.,
EXNER M.,
ZEDWITZLIEBENSTEIN K.,
THALHAMMER F.,
GEORGOPOULOS A.,
GRANINGER W.,
LOOAREESUWAN S.
Publication year - 1996
Publication title -
clinical & experimental immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.329
H-Index - 135
eISSN - 1365-2249
pISSN - 0009-9104
DOI - 10.1046/j.1365-2249.1996.d01-723.x
Subject(s) - malaria , plasmodium falciparum , immunology , medicine , cd14 , tumor necrosis factor alpha , gastroenterology , immune system
Serum sCD14, tumour necrosis factor‐alpha (TNF‐α), IL‐6, and endotoxin were analysed in 45 patients with complicated malaria, in 14 patients with Gram‐negative septicaemia and in 24 healthy subjects by ELISA. Malaria patients with renal failure ( n =16) had higher levels than patients without renal failure ( n =29) (8116+1440 μg/ l versus 9453+1017 μg/ l P <0.05) and both had higher levels than patients with septicaemia (6155+1635μg/ l ) and normal subjects (2776+747 μg/ l ). A significant correlation between sCD14 and IL‐6 ( r =0.756) and TNF ( r =0.822) existed. However, no relation between sCD14 and serum endotoxin or indices of clinical disease severity (parasitaemia, fever, parasite or fever clearance time) was seen. Although the role of sCD14 in malaria remains to be determined, elevated levels may participate in the inflammatory response in complicated malaria.