Open AccessNormal levels of soluble E‐selectin, soluble intercellular adhesion molecule‐1 (sICAM‐1), and soluble vascular cell adhesion molecule‐1 (sVCAM‐1) decrease with age
Author(s) -
NASH M. C.,
WADE A. M.,
SHAH V.,
DILLON M. J.
Publication year - 1996
Publication title -
clinical & experimental immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.329
H-Index - 135
eISSN - 1365-2249
pISSN - 0009-9104
DOI - 10.1046/j.1365-2249.1996.925616.x
Subject(s) - cell adhesion molecule , von willebrand factor , e selectin , intercellular adhesion molecule 1 , soluble cell adhesion molecules , immunology , cell adhesion , selectin , adhesion , intracellular , chemistry , cell , biology , microbiology and biotechnology , platelet , biochemistry , organic chemistry
sE‐selectin, sICAM‐1, sVCAM‐1 and von Willebrand factor (vWF) were assayed in 238 samples in a longitudinal study of 81 normal children from 9.5 to 15.5 years old. Multilevel modelling was used to quantify changes with age. sE‐selectin, sICAM‐1 and sVCAM‐1 all fell significantly over the age range (by 17%, 16%, and 10%, respectively). In contrast, levels of vWF were not age‐dependent. Our findings highlight the need for age‐matched controls when studying cell surface adhesion molecules in disease groups, and may imply developmental changes in expression of these molecules and their shedding from the cell surface.