Open AccessGeneralized immune activation in pulmonary tuberculosis: co‐activation with HIV infection
Author(s) -
VANHAM G.,
EDMONDS K.,
QING L.,
HOM D.,
TOOSSI Z.,
JONES B.,
DALEY C. L.,
HUEBNER R.,
KESTENS L.,
GIGASE P.,
ELLNER J. J.
Publication year - 1996
Publication title -
clinical & experimental immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.329
H-Index - 135
eISSN - 1365-2249
pISSN - 0009-9104
DOI - 10.1046/j.1365-2249.1996.907600.x
Subject(s) - neopterin , immunology , immune system , tuberculosis , cd8 , cd38 , medicine , immunopathology , biology , pathology , cd34 , genetics , stem cell
Parameters of immune activation/differentiation were studied in a group of newly diagnosed HIV − and HIV + pulmonary tuberculosis (TB) patients. Compared with controls, HLA‐DR expression on both CD4 and CD8 T cells from the HIV − TB patients was approximately doubled; HLA‐DR on T cells from the HIV + group was tripled. The monocytes from both groups of patients expressed abnormally high levels of the Fcγ receptors I and III. Serum levels of tumour necrosis factor‐alpha (TNF‐α), neopterin and β 2 ‐microglobulin were increased in HIV − and even more so in HIV + TB patients. The expression of HLA‐DR on T cell subsets and of FcγR on monocytes correlated with each other, but not with serum activation markers. This pattern of non‐specific activation during TB infection may be associated with enhanced susceptibility to HIV infection.