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The treatment of basal skin carcinomas in two sisters with xeroderma pigmentosum
Author(s) -
Roseeuw D.
Publication year - 2003
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1046/j.1365-2230.28.s1.10.x
Subject(s) - xeroderma pigmentosum , dermatology , medicine , basal cell carcinoma , photodermatosis , basal cell , pathology , biology , genetics , dna repair , gene
Summary Xeroderma pigmentosum (XP) is a rare autosomal recessive disorder that causes defects in the DNA repair system. It is characterized by a marked sensitivity to sunlight, and sufferers develop serious sunburns with onset of poikilodermia in the light‐exposed skin. Squamous cell carcinomas, basal cell carcinomas (BCCs) and malignant melanomas appear in childhood. Two sisters with XP presented with previously treated facial BCCs. They were treated with imiquimod 5% cream three times weekly, one for 6 weeks and the other for 10 weeks. Although both sisters temporarily discontinued treatment due to severe erythema and erosion, successful long‐term clearance was observed with no recurrences in both cases.