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Co‐existent primary cutaneous anaplastic large cell lymphoma and lymphomatoid papulosis
Author(s) -
Dawn G.,
Morrison A.,
Morton R.,
Bilsland D.,
Jackson R.
Publication year - 2003
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1046/j.1365-2230.2003.01406.x
Subject(s) - lymphomatoid papulosis , medicine , anaplastic large cell lymphoma , cd30 , dermatology , lymphoma , cutaneous lymphoma , pathology , lymphoproliferative disorders , mycosis fungoides
Summary We describe the case of a 37‐year‐old female with a history of psoriasiform dermatitis who presented with multicentric primary cutaneous CD30‐positive anaplastic large T cell lymphoma (ALCL). Despite aggressive systemic therapy, the patient suffered multiple relapses and the lymphoma spread to cervical and inguinal lymph nodes. Later in her clinical course it was appreciated that she was also suffering from lymphomatoid papulosis (LyP). The case illustrates the overlapping clinical, histological and immunophenotypic features of ALCL and LyP, conditions which represent a spectrum of CD30‐positive lymphoproliferative disease. A multidisciplinary approach between dermatologist, oncologist and pathologist is essential for the optimal management of these complex conditions.