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Type I lamellar ichthyosis improved by tazarotene 0.1% gel
Author(s) -
Marulli G. C.,
Campione E.,
Chimenti M. S.,
Terrii A.,
Melino G.,
Bianchi L.
Publication year - 2003
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1046/j.1365-2230.2003.01318.x
Subject(s) - dermatology , medicine , art history , library science , art , computer science
Summary The efficacy of tazarotene 0.1% gel in a 30‐year‐old woman with type I lamellar ichthyosis is reported. The drug was applied to 15% of the total body surface area as follows: once daily for 2 weeks, three times a week for further 2 weeks, followed by a once weekly maintenance application. During the first week of treatment there was partial improvement obtained and in the next 14 days further reduction of scaling within the tazarotene‐treated areas was observed. After 4 months of maintenance application, there was a marked overall improvement in the treated areas. Side‐effects consisted only of mild pruritus, slight burning and irritation. In essence, the therapeutic benefit obtained was comparable with that of systemic retinoids but without the adverse systemic side‐effects. As noted in other reports, tazarotene 0.1% gel seems to be a valuable and safe therapeutic option for this severe genodermatosis.