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A new extended haplotype Cw*0602‐B57‐DRB1*0701‐DQA1*0201‐DQB1*0201 associated with psoriasis in the Croatian population
Author(s) -
Kaštelan M.,
Gruber F.,
ČečukJeličić E.,
Grubić Z.,
Kaštelan A.
Publication year - 2003
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1046/j.1365-2230.2003.01215.x
Subject(s) - haplotype , allele , psoriasis , relative risk , population , genetics , croatian , human leukocyte antigen , biology , immunology , medicine , gene , antigen , confidence interval , linguistics , philosophy , environmental health
Summary In this study, we have analysed the distribution of HLA class II alleles and the extended haplotype HLA‐Cw‐B‐DRB1‐DQA1‐DQB1 in Croatian patients with type I and type II psoriasis by hybridization with specific oligonucleotide probes. Type I psoriasis showed a significant association with the DRB1*0701 [ P < 0.00001; relative risk (RR) = 5.83], DQA1*0201 ( P < 0.00001; RR = 6.12), DQB1*0201 ( P = 0.0006; RR = 3.29) and DQB1*0303 alleles ( P = 0.0008; RR = 7.51). A negative correlation with type I disease was observed for the DQA1*0102 allele ( P = 0.002; RR = 0.26). Type II psoriasis did not show any association with any class II alleles. The extended haplotype HLA‐Cw*0602‐B57‐DRB1*0701‐DQA1*0201‐DQB1*0201 was present at a significantly higher frequency in type I patients ( P < 0.00001; RR = 7.72). However, this haplotype was not detected at all in patients with type II psoriasis. In conclusion, the extended haplotype HLA‐Cw*0602‐B57‐DRB1*0701‐DQA1*0201‐DQB1*0201 is a risk haplotype for type I disease in the Croatian population. This particular haplotype has not been reported previously in association with psoriasis in any other ethnic groups.