Giant condyloma of Buschke–Loewenstein in association with erythroderma

Summary The Buschke−Loewenstein tumour is regarded as a type of verrucous carcinoma occurring on anogenital mucosal surfaces. The tumour is locally invasive but displays a benign cytology and rarely metastasizes. It is associated with human papillomavirus types 6 and 11. We describe a case of Buschke−Loewenstein tumour occurring in a 61‐year‐old man which behaved in a locally aggressive manner and was associated with human papillomavirus type 16 and erythroderma which proved resistant to treatment. The patient refused surgery and therapy with interferon α was ineffective. Chemotherapy with systemic cisplatin and 5‐fluorouracil produced a partial response before the patient succumbed from gram‐negative septicaemia.