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Giant condyloma of Buschke–Loewenstein in association with erythroderma
Author(s) -
Antony F. C.,
ArdernJones M.,
Evans A. V.,
Rosenbaum T.,
RussellJones R.
Publication year - 2003
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1046/j.1365-2230.2003.01167.x
Subject(s) - medicine , erythroderma , dermatology , human papillomavirus , verrucous carcinoma , chemotherapy , alpha interferon , pathology , carcinoma , immunology , interferon
Summary The Buschke−Loewenstein tumour is regarded as a type of verrucous carcinoma occurring on anogenital mucosal surfaces. The tumour is locally invasive but displays a benign cytology and rarely metastasizes. It is associated with human papillomavirus types 6 and 11. We describe a case of Buschke−Loewenstein tumour occurring in a 61‐year‐old man which behaved in a locally aggressive manner and was associated with human papillomavirus type 16 and erythroderma which proved resistant to treatment. The patient refused surgery and therapy with interferon α was ineffective. Chemotherapy with systemic cisplatin and 5‐fluorouracil produced a partial response before the patient succumbed from gram‐negative septicaemia.