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Topical photodynamic therapy in disseminated superficial actinic porokeratosis
Author(s) -
Nayeemuddin F. A.,
Wong M.,
Yell J.,
Rhodes L. E.
Publication year - 2002
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1046/j.1365-2230.2002.01164.x
Subject(s) - medicine , photodynamic therapy , dermatology , clearance , hyperpigmentation , porokeratosis , actinic keratoses , dyskeratosis , actinic keratosis , photodermatosis , hyperkeratosis , pathology , basal cell , dna , chemistry , genetics , organic chemistry , xeroderma pigmentosum , biology , urology , dna damage
Summary Photodynamic therapy (PDT) has been reported to be useful in treating certain nonmelanoma skin cancers and a variety of benign skin conditions. We examined whether PDT might be effective in the treatment of disseminated superficial actinic porokeratosis. Three patients with classical disseminated superficial actinic porokeratosis had a small test area treated with topical aminolaevulinic acid PDT. Following the first treatment, the disorder cleared in the test area in one patient, but failed to respond in the other two patients. After subsequent treatment, the initial benefit seen in the first patient was not sustained, and no response was seen in the second patient, while the third patient was not retreated due to hyperpigmentation induced by the procedure. The results obtained in this small case series suggest that topical PDT is not a promising treatment for disseminated superficial actinic porokeratosis.