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Dyschromatosis universalis hereditaria
Author(s) -
Sethuraman G.,
D'Souza M.,
Thappa D. Mohan,
Srinivas C. R.,
Smiles L.
Publication year - 2002
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1046/j.1365-2230.2002.01129.x
Subject(s) - dermatology , medicine , pigmentation disorder , abnormality , etiology , hyperpigmentation , histopathology , melanin , alopecia universalis , nail (fastener) , melanosome , pathology , biology , materials science , psychiatry , metallurgy , genetics , scalp
Summary Dyschromatosis universalis hereditaria is a clinically heterogenous disorder. We report two unrelated Indian patients with dyschromatosis universalis hereditaria, who had generalized and progressive reticulate hyper‐ and hypo‐pigmentation of the skin. The oral mucosa and tongue also showed mottled pigmentation. Intriguingly, the palms and soles were also affected with a diffuse hyper‐pigmentation interspersed with spotty de‐pigmented macules. Dystrophic nail changes with pterygium formation were seen in one case. Histopathology revealed a variable degree of pigmentary incontinence. Although the precise aetiology of this disorder is not yet known, the clinicopathological findings implicate an inherent abnormality of melanosomes or melanin processing.