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Topical 5‐ALA photodynamic therapy for the treatment of cutaneous T‐cell lymphoma
Author(s) -
Leman J. A.,
Dick D. C.,
Morton C. A.
Publication year - 2002
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1046/j.1365-2230.2002.01119.x
Subject(s) - photodynamic therapy , medicine , cutaneous t cell lymphoma , dermatology , lymphoma , mycosis fungoides , chemotherapy , surgery , pathology , chemistry , organic chemistry
Summary Therapeutic options for cutaneous T cell lymphoma (CTCL) include topical steroids, topical chemotherapy and phototherapy. Patients with limited disease that is unresponsive to these therapies present a particular challenge. We report successful treatment of a patient with two plaques of CTCL using topical photodynamic therapy (PDT). 5‐aminolaevulinic acid (5‐ALA) was applied 6–24 h preillumination with 100 J/cm 2 red light. Treatment was repeated on four occasions with clinical and histological clearance. ALA–PDT may be a useful addition to the therapeutic options for CTCL. Further studies are required to define optimal treatment protocols.