Premium
Extracellular matrix and keratinocyte migration
Author(s) -
O'Toole E. A.
Publication year - 2001
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1046/j.1365-2230.2001.00891.x
Subject(s) - extracellular matrix , keratinocyte , microbiology and biotechnology , integrin , motility , extracellular , wound healing , collagenase , matrix (chemical analysis) , chemistry , receptor , biology , immunology , in vitro , biochemistry , enzyme , chromatography
We are just beginning to understand some of the cellular mechanisms involved in human keratinocyte migration on extracellular matrix. Extracellular matrix components have differing effects on keratinocyte motility. Signalling through integrin receptors and secretion of collagenase are both components of this process. An understanding of the effect of extracellular matrix on keratinocyte migration has direct relevance to the problem of wound re‐epithelialization and will assist in the development of therapeutic efforts to enhance wound healing artificially.