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The dermatosis of chronic granulomatous disease
Author(s) -
Chowdhury M. M. U.,
Anstey A.,
Matthews C. N. A.
Publication year - 2000
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1046/j.1365-2230.2000.00610.x
Subject(s) - chronic granulomatous disease , context (archaeology) , medicine , disease , immunology , dermatology , pathology , biology , paleontology
A family with X‐linked cytochrome‐negative chronic granulomatous disease (CGD) involving three generations is reported. The diagnosis of CGD in both the latest male patient and the index male was confirmed by marked impairment in polymorphonuclear leucocyte oxidative burst activity in association with absence of both subunits of cytochrome b. The two female carriers have suffered from chronic inflammatory skin disorders characterized by slowly fluctuating erythematous plaques. The reported cases are discussed in the context of a literature review of the dermatosis of CGD.