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Salient features and HLA markers of childhood psoriasis in Kuwait
Author(s) -
Nanda A.,
AlFouzan A. S.,
ElKashlan M.,
AlSweih N.,
AlMuzairai I.
Publication year - 2000
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1046/j.1365-2230.2000.00598.x
Subject(s) - psoriasis , scalp , human leukocyte antigen , medicine , family history , dermatology , immunology , antigen
A total of 305 consecutive Kuwaiti children with psoriasis were studied for clinical features and 50 children were tissue typed for HLA class I and class II antigens. The salient features of psoriasis in these children included: female preponderance (M : F ratio, 1 : 1.5); peak age of onset between 2 and 8 years; scalp as the most common site of onset (30%); scalp and extensors of legs as commonly affected sites (52.5% each); plaque psoriasis the most common clinical type (89%); and a positive family history of psoriasis in 34% of the patients. Kuwaiti children with psoriasis showed a significant association with HLA‐A3, Cw1, and DR7 antigens and those with a positive family history of psoriasis had a significant association with HLA‐DR8 antigen.