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Chloroxylenol and zinc oxide containing cream (Nels cream ® ) vs. 5% benzoyl peroxide cream in the treatment of acne vulgaris. A double‐blind, randomized, controlled trial
Author(s) -
Papageorgiou Pp,
A.C. Chu
Publication year - 2000
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1046/j.1365-2230.2000.00562.x
Subject(s) - benzoyl peroxide , acne , medicine , double blind , dermatology , gastroenterology , chemistry , placebo , pathology , organic chemistry , alternative medicine , polymerization , polymer
Forty‐one subjects completed a double‐blind controlled randomized study comparing the following: (i) Nels cream ® (containing chloroxylenol and zinc oxide); (ii) 5% benzoyl peroxide cream; and (iii) the vehicle of the Nels cream. Patients applied the medications twice daily for 8 weeks. At the end of the test period there was no significant difference in the reduction of inflammatory and noninflammatory lesion counts achieved by Nels cream and benzoyl peroxide. Both creams proved superior to the vehicle. Efficacy grading by subjects and investigators showed no significant difference between Nels cream and benzoyl peroxide. However, side‐effects such as peeling and dryness caused by the treatment were significantly less in the Nels cream group.