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Haematological disease in siblings with Rothmund–Thomson syndrome
Author(s) -
William M. Porter,
Catherine Hardman,
Saad Abdalla,
A.V. Powles
Publication year - 1999
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1046/j.1365-2230.1999.00530.x
Subject(s) - sister , incidence (geometry) , medicine , disease , pediatrics , sibling , dermatology , psychology , developmental psychology , physics , sociology , anthropology , optics
We report two siblings with Rothmund–Thomson syndrome (RTS); the older sister died of acute myeloblastic leukaemia and the younger sister has a slowly progressive leucopenia. Her prognosis is guarded in view of the increased incidence of neoplasms in this condition. More than 200 cases of RTS have now been reported worldwide. 1 This is the first report of siblings with haematological disease and RTS.