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Familial cases of poikiloderma of Civatte: genetic implications in its pathogenesis?
Author(s) -
Alexandros Katoulis,
N. Stavrianeas,
S. Georgala,
Alexandra Katsarou-Katsari,
Elma Koumantaki-Mathioudaki,
Christina Antoniou,
J. Stratigos
Publication year - 1999
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1046/j.1365-2230.1999.00508.x
Subject(s) - genetic predisposition , poikiloderma , disease , dermatology , medicine , sun exposure , pathogenesis , trait , immunology , pathology , computer science , programming language
Poikiloderma of Civatte (PC) is a rather common, benign skin condition of obscure etiopathogenesis: cumulative exposure to UV radiation, hormonal changes associated with the menopause, and photo‐allergic mechanisms have been implicated. We present seven cases of PC among the members of two unrelated Greek families, who have not shared common extrinsic influences. Literature review revealed no other reported familial cases. Familial tendencies, as well as the not unusual occurrence of PC in individuals with minimal sun exposure, and who are not using perfumes or cosmetics, provide support for the hypothesis that a genetic predisposition to the disease may exist; this predisposition is possibly transmitted as an autosomal dominant trait.