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Cutaneous graft‐versus‐host‐like reaction in systemic T‐cell lymphoma
Author(s) -
Scarisbrick,
Wakelin,
RussellJones
Publication year - 1999
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1046/j.1365-2230.1999.00507.x
Subject(s) - lymphoma , medicine , malignancy , cutaneous t cell lymphoma , mycosis fungoides , graft vs host reaction , pathology , lymph node , histology , cytotoxic t cell , systemic disease , immune system , bone marrow , t cell lymphoma , immunology , immunopathology , biology , bone marrow transplantation , biochemistry , in vitro
We report a case of systemic T‐cell lymphoma with cutaneous lesions showing histological features of a cutaneous graft‐versus‐host‐like‐reaction. Histology from liver, lymph node and bone marrow showed a malignant T‐cell infiltrate. T‐cell receptor gene rearrangement studies confirmed the diagnosis. A cutaneous graft‐versus‐host‐like reaction has been reported with disseminated malignancy and one case has been reported with systemic lymphoma. Graft‐versus‐host disease normally occurs when lymphocytes from an immunocompetent donor are introduced into a histo‐incompatible recipient who is incapable of rejecting them. In our patient a similar reaction may have occurred if the lymphoma was composed of cytotoxic cells or if a cell‐mediated immune response against the malignant T‐cells cross‐reacted with epidermal keratinocytes. Alternatively the malignant T‐cells could have been functionally active and induced a lichenoid reaction in the skin.